Biote

Biote Certified Providers

As Biote certified providers, our clinic offers personalized bioidentical hormone replacement therapy (BHRT) designed to help you achieve optimal hormone balance and support long-term wellness.

Certified Providers

• Wendy Lee, MD
• Kristin Etzkorn, DO
• Amanda Robertson, DNP, AGPCNP

At Carolina Rheumatology and Neurology Associates, we have chosen to partner with BioTE because of their dedication to clinical and scientific research. Biote BHRT is made from natural sources which can be identified and used more efficiently than synthetic forms.

Use this link to access Biote Nutraceuticals – a line of supplements formulated to support immune health, cardiovascular health, brain health, etc.

Below is a list of recommended Nutraceuticals. Please discuss any new vitamins, herbs, or supplements with your healthcare provider before starting them to ensure they are safe and appropriate for you.

Nutraceuticals List

• A combination of vitamins A, D3, and K2, which are essential for bone health in both men and women. Recommended for at-risk populations including those diagnosed with osteoporosis, vitamin deficiencies, current fractures, or the elderly.  Useful for healthy bones, calcium absorption, gut health, cardiovascular health, and immune health.
  • Vitamin A plays a role in skeletal development and bone remodeling.  
  • Vitamin D is an essential component of overall bone health. Deficiency in vitamin D may lead to loss of bone mineralization. Daily supplementation is often recommended, especially for at-risk populationsincluding those with deficiency and the elderly.  
  • Vitamin K helps to support bone quality and strength. Also, vitamin K and D provided greater benefits when taken together. 

• The endothelial glycocalyx is a thin layer lining the walls of blood vessels. This lining plays a major role in maintaining vascular balance. Arterosil HP contains the extract of a rare green seaweed, which is a valuable source of vitamins and minerals that help to promote vascular health. This extract is combined with a blend of fruits and vegetables. 
  • Monostroma nitidum (green seaweed) extract is nutrient rich which have been shown to exhibit therapeutic effects 

• Bacillus coagulans is a probiotic bacterium which has shown positive effects on gastrointestinal disorders from diarrhea to constipation. 
  • In both preclinical and clinical studies, Bacillus coagulans reduced gastrointestinal symptoms (bloating, pain, etc), improved stool consistency, and improved quality of life. 

• A combination of well-researched plant-based extracts with L-theanine and melatonin to help relax the mind, fall asleep faster, and stay asleep longer.  
  • L-theanine is an amino acid commonly associated with relaxation, stress relief, and improved sleep quality. Additionally, other reported benefits include improved cognition and neuroprotection. Some preclinical studies suggest a role in cancer drug bioavailability, mental health disorders, and neurodegenerative disease, although, further clinical studies are needed to substantiate the benefits. 
  • Melatonin is a hormone naturally produced in the body by the pineal gland. Oral melatonin is often suggested for patients with sleep-wake disorders. Data for efficacy is most robust for help in falling asleep. Emerging evidence suggests melatonin demonstrates antioxidant, anti-inflammatory, relaxation, neuroprotective, and immunomodulatory properties. 

• BPC-157 is a polypeptide made up of 15 amino acids. It has shown beneficial effects on immune health, GI disease, wound healing, central nervous system disorders, and cardiovascular health.
• KPV is known for its potent anti-inflammatory properties, especially noted for efficacy in GI and skin disorders.

• Curcumin is the biologically active form of turmeric, which has been known for its antioxidant, anti-inflammatory, and wound-healing properties. It has been combined with a phospholipid complex derived from sunflowers to improve bioavailability. 
  • Curcumin has been used for centuries in traditional medicines like Chinese medicine and Ayurveda. Anecdotal evidence suggests therapeutic benefits in conditions like arthritis, neurodegenerative disease, and hyperlipidemia. 
  • Multiple meta-analyses and systemic reviews showed improved clinical outcomes in patients with inflammatory disease. 

• DIM is a natural compound formed when ingesting cruciferous vegetables (ie. broccoli). DIM is involved in hormone metabolism, inflammation, detoxification, and cell growth. DIM has also demonstrated possible anti-tumor activity in studies. 
  • DIM is recommended for patients with disease associated with inflammation and cardiovascular issues due to noted antioxidant and anti-inflammatory effects.  
  • DIM has shown anti-tumor activity in pre-clinical studies, especially hormone-driven cancers (ie. breast, prostate) 
  • DIM has demonstrated improvement in breast tenderness in patients receiving hormone replacement therapy. 

• Her-T is a combination of naturally-derived nutrients designed to support testosterone balance in women. Symptoms of low testosterone in women include decreased libido, mood imbalance, fatigue, and an overall poor sense of well-being.
  • Leteolin is a naturally occurring flavonoid found in many fruits, vegetables, nd herbs. It is well-known for a wide spectrum of benefits including anti-cancer, neuroprotective, antioxidant, antiviral, anti-inflammatory, cardioprotective, and antimicrobial properties.
  • Secoisolariciresinol diglucoside (SDG) is a plant extract most commonly found in flaxseed. It has become a promising nutraceutical exhibiting positive cardiovascular health, cancer prevention, osteoarthritis, anti-inflammatory, neuroprotective, and metabolic disease benefits. SDG has also shown promising effects on reducing uric acid, alleviating allergies, and improving intestinal function.
  • Gingerols are compounds naturally found in ginger rhizomes. They exhibit a multitude of pharmacological properties including anti-inflammatory, anti-cancer, antioxidant, antidiabetic, neuroprotective, cardioprotective, and GI regulatory effects.
  • Spermidine is naturally occurring and functions as a regulator of cellular homeostasis. Well known for it’s anti-aging properties.

• His-T is a combination of naturally-derived nutrients designed to support male testosterone balance, prostate health, sexual health, and healthy cortisol levels. Symptoms of low testosterone in men include decreased libido, erectile dysfunction, low energy, decreased muscle mass, fatigue, and poor concentration.
  • Protodioscin is a naturally occurring steroid compound derived from various plant species. This compound has been researched substantially for antioxidant, anti-cancer, and anti-inflammatory qualities. Other reported positive benefits include pain relief and anti-diarrhea effects.
  • Secoisolariciresinol diglucoside (SDG) is a plant extract most commonly found in flaxseed. It has become a promising nutraceutical exhibiting positive cardiovascular health, cancer prevention, osteoarthritis, anti-inflammatory, neuroprotective, and metabolic disease benefits. SDG has also shown promising effects on reducing uric acid, alleviating allergies, and improving intestinal function.
  • Ursolic acid is a compound found in a variety of plants, fruits, and vegetables. This compound exhibits a broad spectrum of pharmacological benefits that have been extensively studied. Unsolicited acid demonstrates cardioprotective, antioxidant, anti-inflammatory, anti-diabetic, anti-cancer, and anti-microbial properties.
  • Spermidine is naturally occurring and functions as a regulator of cellular homeostasis. Well known for its anti-aging properties.

• Iron deficiency can present with a multitude of symptoms including fatigue, weakness, shortness of breath of breath, dizziness, restless legs, and irritability. Severe iron deficiency can contribute to cardiovascular symptoms including paleness, elevated heart right, and angina. Untreated iron deficiency often leads to anemia and hemodynamic instability.
  • Ferrochel is an iron amino acid compound with an absoprtion rate of approximately twice that of ferrous sulfate. It is more easily absorbed and associated with fewer complaints of abdominal pain, constipation, and nausea compared to ferrous sulfate.

• Methyl Factors+ is a combination of nutrients that support methylation, a naturally occurring process that helps to maintain the body’s homocysteine levels. This process significantly affects regulation of the cardiovascular, reproductive, and neurological systems. Elevated homocysteine levels increases the risk for developing cardiovascular disorders, osteoporosis, and neurodegenerative disorders. Methyl Factors+ is a combination of riboflavin, vitamin B6, folate, vitamin B12, and betaine in the most bioavailable forms. 
  • Riboflavin, or vitamin B2, plays a role in multiple processes including energy, cellular function, and vitamin metabolism. Riboflavin must be obtained through diet through sources like meat, milk, and green vegetables. 
  • Vitamin B6 is dependent upon riboflavin for activation. B6 is especially beneficial for patients with the MTHFR mutation. Positive effects on homocysteine levels are most pronounced with used in combination with riboflavin, B12, and folate. 
  • Folate, vitamin B9, plays a key role in maintaining appropriate levels of homocysteine.  
  • Vitamin B12, cobalamin, is also essential for maintaining appropriate levels of homocysteine. Low levels of vitamin B12 may cause megaloblastic anemia or abnormal neurological symptoms. 
  • Betaine helps with methylation and maintaining homocysteine levels, especially in patients with folate deficiencies. 

• Biote’s multi-strain probiotic contains two strains of lactobacillus and two strains of bifidobacterium.  
  • Lactobacillus acidophilus is naturally found in the human GI tract. This bacteria is able to survive highly acidic and bile-rich environments, which allows for colonization and exertion of beneficial effects over time. 
  • Lactobacillus paracasei is also naturally found in the human GI tract. Beneficial effects include lowering cholesterol, antioxidant, and antimicrobial activities. 
  • In clinical studies, Bi-04 has shown potential benefits for maintaining gut microbiota, neutralizing toxins, and enhancing immune function.
  • Meta-analyses have shown that Bi-06 can improve stool consistency and reduce colonic transit time. 

• NAD+ is an essential coenzyme involved in cellular energy metabolism. NAD levels naturally decline with age. Benefits of NAD supplementation include cardiovascular health, brain health, cellular health, anti-aging, and muscle health.
  • Niagen, a specialized form of vitamin B3, has been studied in depth clinically. Pre-clinical trials have shown potential benefits for anti-aging, metabolic health, improved glucose tolerance, reduced fatty liver, and neuroprotection.
  • NAD+ 300 is recommended as a daily supplement for healthy individuals.
  • NAD+ 1000 is recommended for individuals with demanding physical levels and greater exposure to metabolic stressors.

• Combination Omega 3 and CoQ10 may provide beneficial effects on the cardiovascular and neurological symptoms. 
  • Omega 3 fatty acids are known for antithrombotic, anti-inflammatory, and cardio-protective qualities. Daily supplementation can help to reduce overall cardiovascular risks. 

• Senolytics work by removing senescent, or old and damaged, cells that remain active by no longer divide. Synolytic complex contains a combination of senolytics, including flavonoids and polyphenols, which may protect cells from stress and age-related damage. 
  • Fisetin is a plant-derived flavonoid that demonstrates anti-cancer, anti-inflammatory, antioxidant, and neuroprotective properties in pre-clinical trials. 
  • Quercetin is most commonly recognized for its antioxidant and anti-inflammatory qualities. Quercetin also exhibits antiviral, antimicrobial, cardioprotective, immunomodulatory, and anticancer activities. 
  • trans-Resveratrol is the active form of resveratrol, which has reported anti-inflammatory, antioxidant, and cardioprotective effects. 
  • trans-Pterotilbene, the bioactive form of stilbene, exhibits anti-diabetic, anti-cancer, antioxidant, anti-inflammatory, and neuroprotective effects. 

• A combination of L-theanine and Relora for natural stress support. 
  • L-theanine has demonstrated modest stress-reduction effects on the body. Evidence supports improvement in subjective stress, physiological stress markers, and anxiety. 
  • Relora is a blend of magnolia and phyllodenron extract which has been shown to offer improvement in perceived stress, salivary cortisol, and transient anxiety. 

• Lactobacillus reuteri is a bacteria that is naturally found in the GI and urogenital tracts. This strain contributes to vaginal health through antimicrobial activity, biofilm formation, microbiome modulation, and immune modulation.
• Lactobacillus rhamnosus is a probiotic known for its role in vaginal health including antimicrobial properties. This strain demonstrates antagonistic activity against bacterial and yeast species. Reduced recurrence of bacterial vaginosis was seen in multiple clinical studies.
• Lactobacillus crispatus is a vaginal strain most strongly associated with optimal vaginal health. It produces large amounts of lactic acid to maintain optimal vaginal pH. Other benefits include anti-inflammatory and antimicrobial properties.
• Lactobacillus gasseri is one of the four dominant vaginal species. It contributes to vaginal health through antimicrobial, activity, lactic acid production, immunomodulation, and epithelial adhesion. This strain also exhibits anti fungal activity against multiple yeast strains.
• Lactobacillus jensenii is also one of the four dominant vaginal species. This strain also contributes to lactic acid production, antimicrobial activity, and hydrogen peroxide generation.